The buzz about it started with an 1997 article from Dr Leung explaining that acne can be reduced with the use of Pantothenic acid. Zempleni, J., Mock, D. M. Human peripheral blood mononuclear cells: Inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor. One of the biggest advantages of using pantothenic acid for acne treatment is the low occurrence of side effects. After reading about pantethine (the active form of B-5), i'm wondering why people aren't trying it instead of b5? They have to be taken on a regular basis to maintain the reserve. If the body can't use the entire vitamin, the extra amount leaves the body through the urine. (Technically, panthenol is a provitamin, a precursor, that our bodies naturally convert into the B5 vitamin.) reduces the synthesis and secretion of oil and promotes sebum breakdown in the skin's oil glands. Because the body uses coenzyme A for hormone production instead of fatty acid metabolism, sebum (skin oil) levels rise and acne follows. How Effective Pantothenic Acid Acne Cure Is? This is how I cleared my acne! Here, I wish to suggest a radically different theory for its pathogene … Pantothenic acid deficiency as the pathogenesis of acne vulgaris Med Hypotheses. Product: The website was eay to navigate, good value and prompt delivery. In 1995, the journal Medical Hypotheses printed a hypothesis by Dr. Lit-Hung Leung, a physician from Hong Kong, which attempted to link vitamin B5 (pantothenic acid) deficiency with acne formation.1 Then, in 1997, the Journal of Orthomolecular Medicine printed an article by Dr. Leung on the same topic.2 The hypothesis was just that, a hypothesis - an initial suggested explanation, in this case without any reputable studies to back up the claim. The main function of this water-soluble B vitamin is in the synthesis of coenzyme A (CoA) and acyl carrier protein [ 1, 2 ]. Acne patients with poor facial skin tend to have reduced quality of life with regard to dissatisfaction about appearance, social impacts and even co-morbid depression. Specifically, the total number of acne lesions in the participants who took vitamin B5 megadoses was reduced by 68%. Comes with our 100% No Questions Asked Money Back Guarantee! Supplementing with megadoses of vitamin B5 allows for enough circulating B5 to address both bodily processes, thus curing acne.2, Upon first reading of Dr. Leung's hypothesis, the reasoning seemed to make common sense. I should note that his paper was not a medical study, it was a hypothesis paper published in Journal of Orthomolecular Medicine.The journal’s scientific standards may be less than rigorous. In the study, the researchers randomly divided 41 participants with mild-to-moderate acne into two groups: - Group 1 took four vitamin B5 supplement pills a day, adding up to a daily megadose of 2.2 g, for 12 weeks. Pantothenic acid is optically active, with maximum biological activity only in the D-form. Linus Pauling Institute Micronutrient Information Center. A total of 10 grams per day were given in 4 divided doses. It also contributes to the normal synthesis of our natural steroid hormones and nerve chemicals called neurotransmitters. From the age of 12 onwards, I was plagued with terrible acne. I had a bump on the side of my face that had been there for years. Food Almost all plant- and animal-based foods contain pantothenic acid in varying amounts. Another study had 10 subjects taking 2.2 g of pantothenic acid a day for 8 weeks; however, this study also had no control group, the pantothenic acid supplements contained 8 other nutrients, and the same conflicts of interest are there. Leung, L. H. Pantothenic acid as a weight-reducing agent: fasting without hunger, weakness and ketosis? Anti-Acne Effect of Pantothenic Acid. Accutane. How Effective Pantothenic Acid Acne Cure Is? Vitamin B 5 (Pantothenic Acid) reduces Acne. In fact, it’s nothing short of an essential nutrient. 13 August 2009. Vitamin B5 (also known as pantothenic acid) is a water-soluble B vitamin and is one of the eight core B vitamins our bodies absolutely need to function at their highest, healthiest level. Pantothenic acid acne treatment. However, they noted that the study was short and cautioned that we need more research to determine whether taking vitamin B5 supplements over the long term might be safe and effective against acne.3. Your email address will not be published. Pantothenic acid (also known as vitamin B5) is an essential nutrient that is naturally present in some foods, added to others, and available as a dietary supplement. Acne.org does not advertise. After 12 weeks, the researchers assessed the participants' acne and found that Group 1 had significantly fewer acne lesions than Group 2. It i Pantothenic acid, also called vitamin B 5 is a water-soluble B vitamin and therefore an essential nutrient. Since doing these steps I saw major results and I haven't had acne since! Let’s fix that now. The point of this post is to take a critical look at the claims that you can treat acne with B5, and the paper by Dr. Leung that started it all. 1 Then, in 1997, the Journal of Orthomolecular Medicine printed an article by Dr. Leung on the same topic. YouTube and Instagram are popular places to share, but anywhere is fine :-). Ascorbyl Glucoside Vitamin C: Avène A-Oxitive, Busting Retinoid Skincare Myths (with Video), Common Questions About Vitamin C (video collab with Beck Wynta), Fenty Skin Start’rs Skincare Range review, « Why Coconut Oil Is the Best Hair Oil (and How to Use It), Rimmel The Only 1 Lipstick swatches and review », Purging vs Breakouts: When to Ditch Your Skincare, Easy (5 Minute) DIY Vitamin C Serum Recipe, My Routine for Starting on Tretinoin (Retin-A) Cream, Pantothenic acid is used by the body to make Coenzyme A, Coenzyme A is required for making hormones and metabolising fats, If you don’t have enough pantothenic acid, you won’t have enough coenzyme A. Pantothenic acid also may help in reducing stress by supporting the adrenal gland to produce stress-related hormones. In this article, Dr Leung explains that acne can be reduced or eliminated with the use of Vitamin B5, also called pantothenic acid. They were also given a cream to use which contained 20% Pantothenic Acid. B5 Pantothenic Acid While I have not tried this exact brand per say, I am familiar with the main ingredient B5 Pantothenic Acid. The truth of the matter is that very little research exists. Improves Lipid Profile. Do red/dark marks from previous acne linger on your skin? Pantothenic acid is safe, even at high doses. By the time I was 32, after 20 years of suffering, I still had severe breakouts on my face, arms, back and chest. Pantothenic acid helps your body fight acne internally by increasing the levels of Coenzyme A and Glutathione within the cells. I don't think its crazy to try and rid acne (cause i would do anything to get rid of it), but taking such high doses doesn't seem very smart. In 1995, the journal Medical Hypotheses printed a hypothesis by Dr. Lit-Hung Leung, a physician from Hong Kong, which attempted to link vitamin B5 (pantothenic acid) deficiency with acne formation. 9 July 2009. Vitamin B5, also called pantothenic acid, is one of the most important vitamins for human life. Medline Plus: Trusted Health Information for You. Pantothenic acid is another name for the vitamin B5. Pantothenic acid, also called vitamin B 5 is a water-soluble B vitamin and therefore an essential nutrient. We need more studies like this before we can say with any confidence that vitamin B5 really helps with acne. Vitamin B5 Pantothenic Acid 500 mg Capsules - 100 pcs (3+ Month Supply) of Rapidly Disintegrating Capsules, Each with 500mg of … LE FAIR COMPLEXION FORMULA IS made in our USA GMP compliant lab and tested for quality and purity! To make educated conclusions, double-blind, controlled research will be required. 2 The hypothesis was just that, a hypothesis - an initial suggested explanation, in … It is sweet with a bitter aftertaste. According to Mayo Clinic.com, the human body needs vitamins, such as pantothenic acid, in small amounts and most are available from food. The George Mateljan Foundation. They are water-soluble, which means that the body can't store them. Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. This version of the medication can be found in some local drug stores, reputable online resources, and may be obtained from the pharmacy with a prescription from a doctor or dermatologist.Most creams contain a therapeutic dose of 20% pantothenic acid and are well tolerated by the skin, leaving no unsightly red or inflamed areas. Vitamin B5 is found in most vegetables as well as in nuts, legumes (beans and peas), poultry, and even dairy products. Participants were also asked to apply a cream to affected areas 4 – 6 times per day. Pantothenic acid (vitamin B5) is contained in numerous multivitamin preparations, for example, in the form of tablets, capsules, effervescent tablets and as syrups. Add this B5 supplement to your diet to unclog your pores, improve healthy skin cell growth, and protect your skin with powerful antioxidants. Generally speaking, if you're eating a varied diet that includes vegetables and lean meats, you probably have no reason to worry. However, … Pantothenic Acid Acne Study. However, despite the quality of the study, we must keep in mind that it was sponsored by a marketing company, which might have influenced the conclusions. Leung, L. H. A stone that kills two birds: How pantothenic acid unveils the mysteries of acne vulgaris and obesity. Your body needs vitamin B5 to 10 Pantothenic acid has been found to help your skin recover from acne. Pantothenic Acid, Vitamin B5 for Acne. Do you have acne on your back and/or chest? Vitamin B5 (pantothenic acid) is a component of Coenzyme A. Coenzyme A is necessary for hormone production as well as fatty acid metabolism. For many animals, pantothenic acid is an essential nutrient as it is required to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. These are as follows: The premenstrual stage when many pms symptoms appear including headaches, cramping and … One case in which taking vitamin B5 supplements may be warranted is if you're deficient in this vitamin. If the test shows that you do have a deficiency, your doctor will likely recommend a supplement. We have only one study so far that shows that megadosing on vitamin B5 orally may help reduce acne, but the study was small, and was sponsored by a marketing company, so we will need to see it replicated before we make any calls on whether vitamin B5 works for acne. Product: I took them for my acne as I saw online pantothenic acid works well. to 5 mg zinc), Copper Gluconate 1.79 mg (equiv. After 20 years of trying every topical treatment you can think of, B5 is the first oral treatment I tried and so far it's the only thing that ever worked. Pantothenic Acid Summary. Take along with your antiaging, antiwrinkle facial moisturizer! How does it work? It’s necessary for making blood cells, and it helps you convert the food you eat into energy. to 250 mcg copper), Silicon Dioxide 10.7 mg (equiv. It is very easy and comforting for us to believe that the lack of pantothenic acid is the only cause and cure for acne problem. All rights reserved. We have almost no evidence supporting the hypothesis, but many companies (Vilantae is perhaps the most well known) market B5 to acne sufferers. Pantothenic acid, also known as vitamin B5, cannot be manufactured by humans and is obtained exclusively from the diet. Provitamin B5 (or panthenol) is the alcohol form of vitamin B5 or pantothenic acid. Function. I carefully looked through many of your reviews on B5 in the reviews and ratings section of acne.org. One 2014 Canadian-led study found that when people with high levels of LDL cholesterol were given 300mg of vitamin B5 every day over 16 weeks, their levels of this ‘bad’ cholesterol dropped significantly. Pantethine isn't a vitamin, but it has proven useful in lowering blood lipids. 1 Then, in 1997, the Journal of Orthomolecular Medicine printed an article by Dr. Leung on the same topic. In an older clinical study, acne vulgaris was effectively treated with both oral and topical pantothenic acid in 100 patients.6 Mucocutaneous adverse reactions caused by isotretinoin therapy have been effectively treated with dexpanthenol 5% cream.7 A pilot study found dexpanthenol 5% as effective as hydrocortisone in atopic dermatitis.8 It is nothing but an oversimplification of a complex problem. Keep in mind that placebo tends to work (about 30%) in clearing acne. https://www.ncbi.nlm.nih.gov/pubmed/7476595, http://orthomolecular.org/library/jom/1997/articles/1997-v12n02-p099.shtml, https://pubmed.ncbi.nlm.nih.gov/24831048/, https://pubmed.ncbi.nlm.nih.gov/31527485/, https://lpi.oregonstate.edu/mic/vitamins/biotin, https://lpi.oregonstate.edu/mic/vitamins/pantothenic-acid, https://www.ncbi.nlm.nih.gov/pubmed/8583972, https://www.ncbi.nlm.nih.gov/pubmed/15539319, http://www.whfoods.com/genpage.php?tname=nutrient&dbid=87, https://medlineplus.gov/druginfo/natural/853.html. However, taking very high doses of pantothenic acid supplements (such as 10,000 mg per day) can cause an upset stomach and diarrhea. It is nothing but an oversimplification of a complex problem. One study found that taking a pantothenic acid supplement for 12 weeks "significantly reduced area-specific and inflammatory acne lesions." Pantothenic acid, also known as vitamin B5, is commonly supplemented in large doses to reduce oil production and help rid your skin of acne. It is very easy and comforting for us to believe that the lack of pantothenic acid is the only cause and cure for acne problem. One 2014 Canadian-led study found that when people with high levels of LDL cholesterol were given 300mg of vitamin B5 every day over 16 weeks, their levels of this ‘bad’ cholesterol dropped significantly. Pantothenic acid or vitamin B5 is a promising water-soluble B-complex vitamin that helps in reducing facial acne lesions. Higdon, J., Drake, V. J., Plesofsky, N. Pantothenic Acid. Pantothenic acid is safe and effective for individuals with high level of total … After 1 month, my skin is clearer than it's ever been. There is a huge amount of impressive anecdotal evidence supporting pantothenic acid as an acne treatment. In that situation, your body will preferentially make hormones leaving your fats unmetabolised, The fats will then leak out through your face as sebum. CoA is a cofactor in a wide range of enzymes in energy metabolism and biosynthesis. Leung, L. H. Pantothenic acid deficiency as the pathogenesis of acne vulgaris. This 2.5% benzoyl peroxide treatment is gel-based... Overly dry skin perpetuates the acne cycle... Glycolic Acid (a.k.a. While some have been spared the ordeal of acne, many others have suffered through unsuccessful treatments over years in spite of the best efforts of top dermatologists. Linus Pauling Institute Micronutrient Information Center. Improvement was presented in general terms. Like all B complex vitamins, B5 helps the body convert food into energy. In theory less oil will help acne because the pores will not … For years, the pathogenesis of acne vulgaris has been known to be strongly influenced by hormonal factors. Pantothenic acid (vitamin B5), Dexpanthenol. I accept no advertisements. i personally think it is crazy to take 10 grams of something to try and rid acne. As you read the summary of Dr. Leung's hypothesis below, keep in mind that this is essentially guesswork. Log in. 09 July 2020. In one randomized, controlled, double-blind study, researchers evaluated the effects of 2,200 mg of pantothenic acid daily on 48 subjects diagnosed with mild to moderate forms of acne. Pantothenic acid is chemically unstable, hygroscopic, viscous oil, sensitive to acids, bases, and heat. For more information see, Zinc Gluconate 34.87 mg (equiv. However, there’s the caveat that this trial was sponsored by a marketing company that sells a B5 supplement, and the corresponding author is from a company that conducts research for supplement companies, so there’s a conflict of interest. Many people choose to use pantothenic acid cream for acne. 100 people of Chinese descent (45 males and 55 females) aged 10 – 30 years with severe acne were treated with high-dose pantothenic acid. Finally, if you wish for the most benefit, then try and find a health … In short, this study is littered with holes.". Scientific research studies back up the efficacy and safety of pantothenic acid as an acne treatment, even at large doses. I ever did to work ( about 30 % ) in clearing acne back and/or?... The participants ' acne and promote clear skin were given in 4 divided.! The B vitamins, which help your skin recover from acne share your success to recommend a have! On B5 in the reviews and ratings section of acne.org from a doctor the scientists reported... I carefully looked through many of your reviews on B5 in the Journal of Orthomolecular Medicine printed an article Dr.. For human life have n't had acne since you convert the food you into. 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